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In this research paper we investigate the applicability of real-time generated computer graphics for mono camera lane and vehicle detection algorithms. First we introduce a developed hardware-in-the-loop simulator and describe two solutions for the input of the synthetic images. Then the creation of the camera and environment model used for the tests is focused. Therefore first requirements hold by the lane and vehicle detection algorithms are mentioned and different fields of application are described. Finally we demonstrate the applicability on three scenarios derived from real test drives and compare the results to reality.