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A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics

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2 Author(s)
David Welch ; School of Biological and Health Systems Engineering, Arizona State University, Tempe, 85287, USA ; Jennifer Blain Christen

We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

Published in:

2011 IEEE International Symposium of Circuits and Systems (ISCAS)

Date of Conference:

15-18 May 2011