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An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy

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8 Author(s)
Hughes, M.S. ; Sch. of Med., Washington Univ. in St. Louis, St. Louis, MO, USA ; Marsh, J.N. ; Wallace, K.D. ; Lanza, G.M.
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In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy (If(r)) and a limiting form of Renyi entropy (If,) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy (either If(r) or If,)In this study it is shown that the robustness of If, may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by lowpass filtering of the waveforms, further improvements may be obtained.

Published in:

Ultrasonics Symposium (IUS), 2010 IEEE

Date of Conference:

11-14 Oct. 2010