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Machine-to-Machine (M2M) technologies allow network-to-device communications. M2M covers a wide scope of technologies including sensing and wireless networking protocols. Hazard monitoring applications based M2M such as monitoring using wireless sensor networks (WSNs) are challenged by real-time and interference-aware requirements. The designed communication mechanisms need to guarantee efficient M2M communication and performance management. In hazard monitoring applications, network topology changes rapidly due to device failures. Cross-layer design is an effective scheme to improve communication performance. In this paper, we propose a novel cross-layer mechanism with joint power control, dynamic link scheduling and routing (JPDSR) in hazard scenarios. The joint mechanism of routing, power control and link scheduling with double frame scheme guarantees a high probability of interference-aware and real-time data delivery in hazard according to event priorities. We conduct simulations and compare it with related work. The simulation results show that our routing has better performance that is more suitable for hazard monitoring applications.