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Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection

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4 Author(s)
Shopova, S.I. ; Microparticle Photophysics Lab, Polytechnic Institute of NYU, Brooklyn, New York 11201, USA ; Rajmangal, R. ; Holler, S. ; Arnold, S.

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We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle’s equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.

Published in:

Applied Physics Letters  (Volume:98 ,  Issue: 24 )