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We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle’s equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.
Published in:
Applied Physics Letters
(Volume:98
,
Issue:
24
)
Date of Publication: Jun 2011
- Page(s):
- 243104 - 243104-3
- ISSN :
- 0003-6951
- Digital Object Identifier :
- 10.1063/1.3599584
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 16 June 2011
- Issue Date :
- Jun 2011
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