By Topic

Liver mitochondrial DNA4977 deletion in alcoholic fatty liver disease and relation to ultrasound

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Liwei Zhuang ; Bio-X Centre and Robotics Institute, Harbin Institute of Technology, Heilongjiang Province,150001, China ; Tao Liang ; Yili Fu

Aim To screen for the mitochondrial DNA 4977bp (mtDNA4977) deletion in the patients with alcoholic fatty liver disease (AFLD). Methods Polymerase chain reaction (PCR) was carried out to detect mtDNA4977 deletion within 90 cases of AFLD plus 90 of normal controls. The ultrasound examination was conducted for the liver tissues of AFLD to compare liver function, blood fat level, body weight, and mtDNA4977 deletion among different ultrasound grades of AFLD. Results With the aggravation of fatty change in live tissues of AFLD, deposition of both triglyceride (TG) and body mass index (BMI) in liver increased significantly (P<;0.05). The mtDNA4977 deletion was detected in 35.56% (thirty-two cases) of the AFLD patients tested and occurred primarily ultrasound grade II or III, giving a significant difference compared to grade 0/I and normal live tissues (P <;0.05). Conclusions A small portion of the AFLD patients had the mtDNA4977 deletion, and this mutation was detected only in high-grade fatty change of AFLD.

Published in:

Complex Medical Engineering (CME), 2011 IEEE/ICME International Conference on

Date of Conference:

22-25 May 2011