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UML sequence diagrams are widely used as a behavioral modeling language for interactive systems for their concise and intuitive expression, especially a few high security systems. However, UML sequence diagrams lack precise formal description of semantics when they are used in modeling of the interactions between objects. To solve the problem, this paper proposes a solution by translating the UML sequence diagrams into a formalization system ALCQI-CTL which combines the features of the description logics and computation tree logic, and then formalizing the static semantics and dynamic semantics of UML sequence diagrams. Finally, the example shows that the formalization method is feasible.