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High-throughput microscopy allows fast imaging of large tissue samples, producing an unprecedented amount of sub-cellular information. The size and complexity of these data sets often out-scale current reconstruction algorithms. Overcoming this computational bottleneck requires extensive parallel processing and scalable algorithms. As high-throughput imaging techniques move into main stream research, processing must also be inexpensive and easily available. In this paper, we describe a method for cell soma detection in Knife-Edge Scanning Microscopy (KESM) using machine learning. The proposed method requires very little training data and can be mapped to consumer graphics hardware, allowing us to perform real-time cell detection at a rate that exceeds the data rate of KESM.