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3D segmentation of rodent brain structures using Active Volume Model with shape priors

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9 Author(s)
Shaoting Zhang ; CBIM, Rutgers, State Univ. of New Jersey, Piscataway, NJ, USA ; Junzhou Huang ; Uzunbas, M. ; Tian Shen
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Object boundary extraction is an important task in brain image analysis. Acquiring detailed 3D representations of the brain structures could improve the detection rate of diseases at earlier stages. Deformable model based segmentation methods have been widely used with considerable success. Recently, 3D Active Volume Model (AVM) was proposed, which incorporates both gradient and region information for robustness. However, the segmentation performance of this model depends on the position, size and shape of the initialization, especially for data with complex texture. Furthermore, there is no shape prior information integrated. In this paper, we present an approach combining AVM and Active Shape Model (ASM). Our method uses shape information from training data to constrain the deformation of AVM. Experiments have been made on the segmentation of complex structures of the rodent brain from MR images, and the proposed method performed better than the original AVM.

Published in:

Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on

Date of Conference:

March 30 2011-April 2 2011

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