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Recent work has demonstrated that using a carefully designed sensing matrix rather than a random one, can improve the performance of compressed sensing. In particular, a well-designed sensing matrix can reduce the coherence between the atoms of the equivalent dictionary, and as a consequence, reduce the reconstruction error. In some applications, the signals of interest can be well approximated by a union of a small number of subspaces (e.g., face recognition and motion segmentation). This implies the existence of a dictionary which leads to block-sparse representations. In this work, we propose a framework for sensing matrix design that improves the ability of block-sparse approximation techniques to reconstruct and classify signals. This method is based on minimizing a weighted sum of the interblock coherence and the subblock coherence of the equivalent dictionary. Our experiments show that the proposed algorithm significantly improves signal recovery and classification ability of the Block-OMP algorithm compared to sensing matrix optimization methods that do not employ block structure.