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The problem of building and maintaining distributed large-scale software applications is really a serious challenge. The processes concerned are hampered by the avalanche of bulky data, which is heterogeneous in structure and architecture. Therewith, an integral methodological approach (which includes not only CASE-level software and technologies, but also rigorous and uniform mathematical models) is required to conquer the complexity and challenges. The approach embraces the entire enterprise software development lifecycle. The methodology suggested simplifies system maintenance due to component-level metadata pattern management, which increase high artifacts reuse, and easily adapt to changeable business requirements. The paper presents the approach outline, and discusses a number of successful implementations based on the pattern management methodology.