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This paper describes the approach and the speedup obtained in performing Smith-Waterman database searches on heterogeneous platforms comprising of multi core CPU and multi GPU systems. Most of the advanced and optimized Smith Waterman algorithm versions have demonstrated remarkable speedup over NCBI BLAST versions, viz., SWPS3 based on x86 SSE2 instructions and CUDASW++ v2.0 CUDA implementation on GPU. This work proposes a hybrid Smith-Waterman algorithm that integrates the state-of-the art CPU and GPU solutions for accelerating Smith-Waterman algorithm in which GPU acts as a co-processor and shares the workload with the CPU enabling us to realize remarkable performance of over 70 GCUPS resulting from simultaneous CPU-GPU execution. In this work, both CPU and GPU are graded equally in performance for Smith-Waterman rather than previous approaches of porting the computationally intensive portions onto the GPUs or a naive multi-core CPU approach.