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Design and characterization of a controlled wet spinning device for collagen fiber fabrication for neural tissue engineering

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3 Author(s)
DeRosa, K.E. ; Dept. of Biomed. Eng., New Jersey Inst. of Technol., Newark, NJ, USA ; Siriwardane, M.L. ; Pfister, B.J.

Type I collagen was extruded into well-defined fibers using a novel controlled wet spinning device. The device significantly improved the yield of collagen fibers on the micron scale. Collagen scaffold materials fabricated from the device will provide contact-guided growth of neuronal cultures. Fibers composed of different weight percentages, 75, 2, and 3.4 wt% collagen dispersions, were used to validate Schwann cell alignment along the fibers. Interestingly, the different concentrations of extruded collagen dispersions demonstrated unique morphologies and directed growth patterns of Schwann cells.

Published in:

Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast

Date of Conference:

1-3 April 2011