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Combined L2-L1-norm regularization in fluorescence diffuse optical tomography

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2 Author(s)
An Jin ; Rensselaer Polytech. Inst., Troy, NY, USA ; Yazici, B.

The inverse problem of fluorescence diffuse optical tomography (FDOT) is often highly ill-posed, which needs regularization techniques. In this paper, we propose a combined l1-l2-norm regularization method to address the ill-posed FDOT inverse problem. Compared with the traditional Tikhonov regularization, the proposed method is able to effectively remove the noise in the reconstructed image without much over-smoothness. The performance of the proposed method is demonstrated in 3D numerical simulation.

Published in:

Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast

Date of Conference:

1-3 April 2011