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To improve the health of the masses, this paper uses the Internet network environment for various aspects of information collection and processing on drugs circulation timely. The system collects information from pharmacies, warehouse, drug production environment and store them into database server of information center by wireless network (GPRS). It implements electronic mapping, office automation and supervision of drug sales, the officials of Food and Drug Administration (FDA) can do some enforcement on site for violations, illegal activities through mobile PDA devices. The drug administration systems that the paper discussed achieves all functions of a modern Drug Administration and management, it improves drug safety supervision and management on drugs circulation channel and drug consumer(person or hospital) and increases the efficiency of administrative or law enforcement.