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Ray Casting Algorithm is a classic rendering approach in volume rendering. It is widely used in the 3D visualization field of medical images, but the rendering speed is very slowly. In order to improve the rendering speed, an high efficient and speed algorithm of Ray Casting based on space leaping and rapid interpolation is presented. Along with a comparing experiment of three kinds of methods in time and drawing quality, the result shows that the accelerate algorithm proposed in this paper can not only get a high quality rendering image, but also improve a rendering speed to a high level. There is some certain value in practical aspect of 3D visualization of medical images.