Cart (Loading....) | Create Account
Close category search window
 

Invited talk: Label-free biosensing with silicon nanowires

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

9 Author(s)
Stern, E. ; Dept. of Biomed. Eng., Yale Univ., New Haven, CT, USA ; Vacic, A. ; Rajan, N. ; Routenberg, D.
more authors

Nanoscale electronic devices have the potential to achieve exquisite sensitivity as sensors for the direct detection of molecular interactions, thereby decreasing diagnostics costs and enabling previously impossible sensing in disparate field environments. Semiconducting nanowire-field effect transistors (NW-FETs) hold particular promise, though contemporary NW approaches are inadequate for realistic applications. We present here a number of top-down fabricated nanowire approaches that are compatible with complementary metal-oxide-semiconductor (CMOS) technology that has not only achieved unprecedented sensitivity, but simultaneously facilitates system-scale integration of nanosensors. These approaches enable a wide range of label-free biochemical and macromolecule sensing applications, such as specific protein and complementary DNA recognition assays, and specific macromolecule interactions at <;femtomolar concentrations. We will also discuss the physics of FET sensing, and device-related limits of potential detection.A critical limitation of nanowire sensors is the Debye screening issue [3] which has to date prevented their use in clinical applications and physiologically relevant solutions. We will present an approach that solves this longstanding problem, and demonstrate the detection at clinically important concentrations of biomarkers from whole blood samples [4].

Published in:

Microelectronics and Electron Devices (WMED), 2011 IEEE Workshop on

Date of Conference:

22-22 April 2011

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.