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Health-care monitoring with Wireless Sensor Networks (WSN) has become a major interest during the last few years. The use of efficient communication protocols is crucial in minimizing transmission delay and energy consumption of sensor nodes. In a heterogeneous WSN context, we propose, efficient mobility aware mechanisms which may be implemented in large three-tier WSN. These mechanisms must be designed to be optimal. The aim of this paper addresses common sensor behavior such as data exchange meanwhile responding to the mobility issue in the fore mentioned context. The mechanisms are based on two main protocols: topology creation and data collection in intra- and inter-tiers. Our mechanisms minimize collisions and optimize the duty-cycle of each node. Furthermore, a performance evaluation study detailed by an analytical model is presented in order to validate the designed protocols.