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Mitotic spindle assembly and chromosome segregation are dynamic processes that require microtubules (MTs), MT-associated motors, MT-binding proteins, and chromosomes to coordinate with each other. Because of the complexity of the system, a thorough understanding of the principles that govern mitotic spindle formation remains elusive. Computational models in biology present an attractive tool to deal with complexity, allowing testing of different hypotheses. Here we developed a computational spatially heterogeneous model of known biochemical interactions involved in spindle formation. Using this model, we investigate the effect that individual species have on spindle morphology and chromosome segregation. Finally, we show the impact that Lamin B, thought to be a component of the long-sought-after spindle matrix, has on spindle formation during mitosis.
Date of Conference: 23-25 March 2011