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The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5·10- 7 RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.