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A Multiscale Graph Theoretical Approach to Gene Regulation Networks: A Case Study in Atrial Fibrillation

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4 Author(s)
Censi, F. ; Italian Nat. Inst. of Health (Ist. Superiore di Sanita), Rome, Italy ; Giuliani, A. ; Bartolini, P. ; Calcagnini, G.

The changes in between gene expression correlation structure induced in heart tissue by atrial fibrillation are studied by means of a graph theoretical approach. As expected by general statistical mechanics principles, the disease increases the general connectivity of the gene regulation network; the multiscale character of the analysis allows us to get both a general appreciation of regulation network connectivity and the sketching of a biological interpretation of the studied disease. The presence of a still largely unknown, scale invariant, global correlation field encompassing the entire genome is demonstrated as well.

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Biomedical Engineering, IEEE Transactions on  (Volume:58 ,  Issue: 10 )