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Integrated analog circuit design in nanometer CMOS technologies brings forth new and significant reliability challenges. Ever-increasing process variability effects and transistor wear-out phenomena such as BTI, hot carrier degradation and dielectric breakdown force designers to use large design margins and to increase the uncertainty on the circuit lifetime. To help designers to tackle these problems at design time (i.e., Design For Reliability, or DFR), accurate transistor aging models, efficient circuit reliability analysis methods and novel design techniques are needed. The paper overviews the current state of the art in DFR for analog circuits. The most important unreliability effects in nanometer CMOS technologies are reviewed and transistor aging models, intended for accurate circuit simulation, are described. Also, efficient methods for circuit reliability simulation and analysis are discussed. These methods can help designers to analyze their circuits and to identify weak spots. Finally, cost-effective design techniques for more resilient and self-healing analog circuits are studied.