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This special issue of the IEEE Transactions on Biomedical Circuits and Systems comprises expanded versions of selected papers presented at the 2010 IEEE International Symposium of Circuits and Systems (ISCAS 2010) held in Paris, France, from May 30 to June 2, 2010. The main theme of ISCAS 2010, Nano-bio circuit fabrics and systems, was highly synergistic with the focus of the Transac tions on emerging advances at the interface between circuits, systems, and biomedicine. Starting from a comprehensive list of 120 papers that were presented at the Biomedical Circuits and Systems, Sensors, Neural Systems, and Live demonstration sessions at the symposium, we selected eight papers which were highly rated by the ISCAS 2010 reviewers and which represented different areas of biomedical circuits and systems. After a thorough peer-review process, we selected a final set of papers for this Special Issue, covering circuits and sys tems-related topics in neural prosthesis, bio-telemetry, power management, and stimulators. While there were undoubtedly many other excellent papers that were presented at the ISCAS 2010, in this compilation, we strived to include high-quality papers that cover diverse areas of interest for the readers of this journal.