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In vivo transcranial and noninvasive cavitation detection with blood-brain barrier (BBB) opening in nonhuman primates is hereby reported. The BBB in monkeys was opened transcranically using focused ultrasound (FUS) in conjunction with microbubbles. A passive cavitation detector, confocal with the FUS transducer, was used to identify and monitor the bubble behavior. During sonication, the cavitation spectrum, which was found to be region-, pressure-, and bubble-dependent, provided real-time feedback regarding the opening occurrence and its properties. These findings demonstrate feasibility of transcranial, cavitation-guided BBB opening using FUS and microbubbles in noninvasive human applications.
Published in:
Applied Physics Letters
(Volume:98
,
Issue:
16
)
Date of Publication: Apr 2011
- Page(s):
- 163704 - 163704-3
- ISSN :
- 0003-6951
- Digital Object Identifier :
- 10.1063/1.3580763
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 25 April 2011
- Issue Date :
- Apr 2011
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