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In this contribution, we describe a newly developed simulation environment for High Speed Downlink Packet Access (HSDPA) in UMTS Release 5 and beyond. The simulation environment implements the downlink physical layer for the High Speed Downlink Shared Channel (HS-DSCH) in detail, whereas the associated signalling messages are idealized as error free. The interference from signalling and data channels on the HS-DSCH is modelled adequately. As a general guideline for system settings in the simulations, we use the test cases specified in 3G TS 25.101 whenever applicable. It is shown that the interference generated by the Synchronization Channel (SCH) and Common Pilot Channel (CPICH) has considerable impact on the error statistics of the HS-DSCH. Therefore, it is worthwhile to implement interference cancellation for the SCH and CPICH in future mobile receivers for HSDPA.