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Microfluidic resonant waveguide grating biosensor system for whole cell sensing

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5 Author(s)
Zaytseva, Natalya ; Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, USA ; Miller, William ; Goral, Vasily ; Hepburn, Jerry
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Your organization might have access to this article on the publisher's site. To check, click on this link:http://dx.doi.org/+10.1063/1.3582611 

We report on a fluidic resonant waveguide grating (RWG) biosensor system that enables medium throughput measurements of cellular responses under microfluidics in a 32-well format. Dynamic mass redistribution assays under microfluidics differentiate the cross-desensitization process between the β2-adrenoceptor agonist epinephrine and the adenylate cyclase activator forskolin mediated signaling. This system opens new possibility to study cellular processes that are otherwise difficult to achieve using conventional RWG configurations.

Published in:
Applied Physics Letters  (Volume:98 ,  Issue: 16 )

Date of Publication: Apr 2011

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