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On-chip cell culture biosensing with microfluidic feedback control

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2 Author(s)
Welch, D. ; Sch. of Biol. & Health Syst. Eng., Arizona State Univ., Tempe, AZ, USA ; Christen, J.B.

We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

Published in:

Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH

Date of Conference:

7-8 April 2011