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On the simultaneous fitting for tracer delay and dispersion in cerebral blood flow studies using oxygen-15 water and PET

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2 Author(s)
Toussaint, P.-J. ; Neurological Inst., McGill Univ., Montreal, Que., Canada ; Meyer, E.

Simulations were used to evaluate the feasibility of simultaneous estimation of CBF, partition coefficient, tracer delay and dispersion in the one-compartment CBF model by curve fitting. The accuracy and precision of these estimates were investigated by means of sensitivity functions. Despite the considerable variability (up to 50%) in the Δt and τ estimates, estimates of CBF were within 5% of their true values

Published in:

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference  (Volume:1 )

Date of Conference:

20-25 Sep 1995