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Comparison of electroporation thresholds of cardiac cell membranes by rectangular and exponential pulses

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2 Author(s)
Tung, L. ; Dept. of Biomed. Eng., Johns Hopkins Univ., Baltimore, MD, USA ; O'Neill, R.J.

Electroporation may be a mechanism for injury to the cardiac cell membrane during electrical defibrillation, if excessive levels of shock are applied. A cell-attached patch-clamp study of single rat ventricular myocytes was conducted to determine whether the voltage thresholds for electroporation differ for two commonly used waveform shapes with widely different tilts: 5 ms rectangular (0% tilt) and 5 ms truncated exponential (67% tilt). When threshold was measured as leading edge voltage, the exponential pulses had, on average, a significantly higher threshold and shorter latency delay for electroporation compared with the rectangular pulses. Therefore, high-tilt exponential pulses may produce less injury via electroporation compared with rectangular pulses

Published in:

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference  (Volume:1 )

Date of Conference:

20-25 Sep 1995