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Toxic element released from high and low carbon CoCrMo alloy in-vitro

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3 Author(s)
Muhamad, N.B. ; Dept. of Bioprocess Eng., Univ. Teknol. Malaysia, Skudai, Malaysia ; Majid, F.A.A. ; Kadir, M.R.A.

Biocompatibility is the mutual coexistence between the biomaterials and the physiological environment where neither has damaging effect on the other. The chemical compositions of CoCrMo alloy released in simulated body fluid will be the main point of concern in this study. The toxic element released (cobalt, chromium, nickel and iron) were analyzed from high carbon and low carbon CoCrMo alloy by inductively couple plasma mass spectrometer (ICPMS). The concentrations of element in low carbon (Cobalt-0.502ppm, Chromium-0.337ppm, Nickel - 0ppm, Ferum - 0ppm) compared to the element in high carbon (Cobalt-0.592ppm, Chromium-0.317ppm, Nickel - 0ppm, Ferum - 0ppm) shows no significant different, and can be represented as a combination of one results (Cobalt-8.75E-3%, Chromium-2.8E-4%, Nickel - 0, Ferum - 0). The average cobalt concentration of elements released were increased in cell culture from high and low carbon is (8.75E-3%) and (6.189E-3%) in RPMI 1640 medium. Nevertheless, (chromium, nickel and iron) element released in a low concentrations and low response in cell culture conditions (2.8E-4%, 0%, 0%) and (2.4E-5%, 0%, 1.18E-3%) in RPMI 1640 medium.

Published in:

Biomedical Engineering and Sciences (IECBES), 2010 IEEE EMBS Conference on

Date of Conference:

Nov. 30 2010-Dec. 2 2010