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Highly-efficient single-cell capture in microfluidic array chips using differential hydrodynamic guiding structures

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3 Author(s)
Chung, Jaehoon ; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, USA ; Kim, Young-Ji ; Euisik Yoon

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This paper presents a highly efficient single cell capture scheme using hydrodynamic guiding structures in a microwell array. The implemented structure has a capturing efficiency of >80%, and has a capacity to place individual cells into separated microwells, allowing for the time-lapse monitoring on single cell behavior. Feasibility was tested by injecting microbeads (15 μm in diameter) and prostate cancer PC3 cells in an 8×8 microwell array chip and >80% of the microwells were occupied by single ones. Using the chips, the number of cells required for cell assays can be dramatically reduced and this will facilitate overcoming a huddle of assays with scarce supply of cells.

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Applied Physics Letters  (Volume:98 ,  Issue: 12 )