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A simple electronic circuit is proposed to simulate bio-communication between neurons of our nervous system. In this model, the variable conductance of postsynaptic membrane of neuron dependence on the neurotransmitter-receptor binding activity is represented by ion sensitive field effect transistor (ISFET). ISFET is chosen as circuit analog because it has potential for on-chip circuit integration leading to the development of lab-on-chip system used in advanced wireless biotelemetry. This analog is incorporated into the famous Hodgkin-Huxley (H-H) model of neuron to substitute the variable Na+ conductance. Simulation is performed in MATLAB environment both for normal and pathologic states.