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A high-sensitivity micromachined biosensor

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5 Author(s)
Baselt, David R. ; Naval Res. Lab., Washington, DC, USA ; Lee, Gil U ; Hansen, K.M. ; Chrisey, L.A.
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The Force Amplified Biological Sensor (FABS) is a desktop or portable instrument currently under development at the Naval Research Laboratory. FABS will use a rapid, automated immunoassay to detect analytes such as proteins, viruses, and bacteria. The assay uses forces produced by micron-sized magnetic particles to pull on antibody-antigen bonds. Microfabricated piezoresistive cantilevers measure the resulting piconewton-level forces with sufficient sensitivity to detect single antibody-antigen bonds. These forces also serve to characterize the bonds, allowing FABS to distinguish specific antibody-antigen bonds from nonspecific interactions

Published in:

Proceedings of the IEEE  (Volume:85 ,  Issue: 4 )