Label free piezoelectric DNA sensor array by selective immobilization via electrochemical method

An 8-pixel quartz crystal resonator array with a fundamental resonance frequency of 73 MHz has been designed and fabricated. We established a protocol for selectively functionalizing the surface of resonator array via electrochemical desorption. The creation of hydrophobic and hydrophilic surface with methyl terminated and carboxylate terminated alkanethiols is characterized by Fourier transform spectroscopy (FTIR) and contact angle measurements. QCMs functionalized with hydrophobic and hydrophilic terminations show a clearly distinguishable response to ionic (buffer) solution.