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Advanced EWOD-based digital microfluidic system for multiplexed analysis of biomolecular interactions

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5 Author(s)
Brassard, D. ; Ind. Mater. Inst., Nat. Res. Council, Boucherville, QC, Canada ; Malic, L. ; Miville-Godin, C. ; Normandin, F.
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This paper presents a low-cost technique for the fabrication of complex electrowetting-on-dielectric (EWOD) digital microfluidic devices. Using this original technology, we have developed devices in which 560 electrodes are used to mix and split nl-size liquid droplets and transport them to 100 analysis spots patterned on a disposable plastic top plate. We demonstrate the multiplexing capability of the developed devices by creating on-chip arrays of droplets with various concentration gradients. Finally, automated biomolecular immobilization and hybridization assays are performed in nl-size droplets under numerous conditions simultaneously with only a limited number of stock solutions.

Published in:

Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on

Date of Conference:

23-27 Jan. 2011