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High-Speed, Single-Photon Avalanche-Photodiode Imager for Biomedical Applications

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5 Author(s)
Palubiak, D. ; Dept. of Electr. & Comput. Eng., McMaster Univ., Hamilton, ON, Canada ; El-Desouki, M.M. ; Marinov, O. ; Deen, M.J.
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The design of a low-light level pixel in CMOS technology for biomedical applications is described. This pixel is also suitable for very high-speed applications, such as fluorescence lifetime imaging (FLIM) used for drug discovery and/or minimally-invasive optical biopsy. In order to achieve high-speed imaging using single-photon detection, a detector with a very low dead-time is needed. The single-photon avalanche-photodiode (SPAD) discussed in this work uses a mainstream deep-submicron CMOS technology in order to achieve ultrahigh-speed operation and high pixel fill-factor, with in-pixel active quench and reset circuits. The paper also presents an innovative approach for reducing the deadtime of the detector and an attractive technique for simultaneous high-speed image acquisition by all the pixels of an array in parallel.

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Sensors Journal, IEEE  (Volume:11 ,  Issue: 10 )