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Battery life specifications drive the power consumption requirements of integrated circuits in implantable, wearable, and portable medical devices. In this paper, we present an embedded processor platform chip using an ARM Cortex-M3 suitable for mapping medical applications requiring microwatt power consumption. Ultra-low-power operation is achieved via 0.5-1.0 V operation, a 28 fW/bit fully differential subthreshold 6T SRAM, a 90%-efficient DC-DC converter, and a 100-nJ fast Fourier transform (FFT) accelerator to reduce processor workload. Using a combination of novel circuit design, system architecture, and SoC implementation, the first sub-microwatt per channel electroencephalograph (EEG) seizure detection is demonstrated.