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Evaluating the Dosimetric Impact of Interfraction Variations During Image-Guided Radiotherapy Using Six-degree-of-freedom Image Registration and Equivalent Uniform Dose Method

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5 Author(s)
Chang-Yu Wang ; Dept. of Radiat. Oncology, Nat. Kaohsiung Univ. of Appl. Sci., Kaohsiung, Taiwan ; Yu-Jie Huang ; Chun-Hsiung Fang ; Jyh-Horng Chou
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This study proposed an off-line method to quantitively analyze the dosimetric impact of daily setup variations on Intensity-modulated radiotherapy (IMRT) when these variations are not corrected due to the lack of image guidance. Series of daily Cone-beam computed tomography (CBCT) images and treatment plan data of a patient with esophageal cancer previously treated using Image-guided radiotherapy (IGRT) were analyzed retrospectively. Daily setup shifts were applied to IMRT plans on a fraction-by-fraction basis using six-degree-of-freedom rigid image registration. The mean interfraction translation displacement was 2.3 ± 1.8, 2.1 ± 0.9, and -1.8 ± 2.6 mm in the LR, AP, and SI directions, respectively. The average interfraction rotation displacement was 2.2 ± 1.2, -0.7 ± 0.8, and -0.7 ± 0.6 degree around the three orthogonal axes. Due to variations, a loss of equivalent uniform dose (EUD) up to 6% for planning target volume (PTV) was noted. Findings confirmed that successful implementation of high precision IMRT required daily image guidance to ensure accurate delivery of sharp gradient dose distributions.

Published in:

Genetic and Evolutionary Computing (ICGEC), 2010 Fourth International Conference on

Date of Conference:

13-15 Dec. 2010

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