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The effect of noise on the process of high-speed remagnetization of vortex state of a pentagonal array of five circular magnetic nanoparticles is studied by means of computer simulation of Landau–Lifshits model. The mean switching time (MST) and its standard deviation (SD) of the reversal between the counterclockwise and clockwise vorticities have been computed. It has been demonstrated that with the reversal by the pulse with sinusoidal shape, the optimal pulse duration exists, which minimizes both the MST and the SD. Besides, both MST and SD significantly depend on the angle between the reversal magnetic field and pentagon edge, and the optimal angle roughly equals 10°. Also, it is demonstrated that the optimization of the angle, duration and the amplitude of the driving field leads to significant decrease in both MST and SD. In particular, for the considered parameters, the MST can be decreased from 60 ns to 2–3 ns. Such a chain of magnetic nanoparticles can effectively be used as an element of magnetoresistive memory, and at the temperature 300 K the stable operation of the element is observed up to rather small size of nanoparticles with the radius of 20 nm.