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Cloud computing can be widely applied to various IT systems to resolve data backup of current systems, as well as data management, system monitoring and so on for it does well in large scale data handling and distributed system management. Firstly, the architecture for information system based on cloud computing is discussed and the concept hierarchical model for cloud computing based information system is proposed as well as the application architecture. Secondly, the construction methods for information system infrastructure are discussed on the basis of cloud computing, and the framework for the cloud computing based information system infrastructure are proposed as well as the cloudlets relationship architecture. Last but not the least, the resource management mechanism for cloudlets is described. The compound framework integrates hierarchical structure and P2P architecture and combines their characteristics that this construction not only manages massive computers and servers effectively but also shares information within the system efficiently.