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Innovation Relay Centre(IRC) is a successful technology transfer network for small and medium-sized enterprises (SMEs). IRC shows many brand-new characteristics of intermediary transfer organizations, and simultaneously increases many new risks. From the view of risk management, the paper comprehensively analyzed the risk factors which affected the IRC operation through factor analysis technology, and obtained environmental risk, technology risk, management risk, financial risk and project selection risk. In order to further confirm the relationship between IRC risk factors and IRC performance factors, the study carried on the regression analysis between the five dimensions and the IRC performance factors. This paper finally summarized the risk factors' influence to IRC, and provided a theoretical guidance to prevent and control the IRC risks.