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Gene selection using 1-norm regularization for multi-class microarray data

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6 Author(s)
Xiaofei Nan ; The University of Mississippi, USA ; Nan Wang ; Ping Gong ; Chaoyang Zhang
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Explosive compounds such as TNT and RDX have various toxicological effects on the natural environment. The goal of the earthworm microarray experiment is to unearth the biomarker for toxicity evaluation. We propose a novel recursive gene selection method which can handle the multi-class setting effectively and efficiently. The selection is performed iteratively. In each iteration, a linear multi-class classifier is trained using 1-norm regularization, which leads to sparse weight vectors, i.e., many feature weights are exactly zero. Those zero-weight features are eliminated in the next iteration. The empirical results demonstrate that the selected features (genes) have very competitive discriminative power. In addition, the selection process has fast rate of convergence.

Published in:

Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on

Date of Conference:

18-21 Dec. 2010