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An algorithm for mapping short reads to a dynamically changing genomic sequence

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4 Author(s)
Flouri, T. ; Dept. of Theor. Comput. Sci., Czech Tech. Univ. in Prague, Prague, Czech Republic ; Holub, J. ; Iliopoulos, C.S. ; Pissis, S.P.

The constant advances in sequencing technology have redefined the way genome sequencing is performed. They are able to produce tens of millions of short sequences (reads), during a single experiment, and with a much lower cost than previously possible. Due to this massive amount of data, efficient algorithms for mapping these reads to reference sequences are in great demand, and recently, there has been ample work for publishing such algorithms. In this paper, we study a different version of this problem: mapping these reads to a dynamically changing genomic sequence. We propose a new practical algorithm, which employs a suitable data structure that takes into account potential dynamic effects (replacements, insertions, deletions) on the genomic sequence. The presented experimental results demonstrate that the proposed approach can be applied to address the problem of mapping millions of reads to multiple genomic sequences.

Published in:

Bioinformatics and Biomedicine (BIBM), 2010 IEEE International Conference on

Date of Conference:

18-21 Dec. 2010