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In this paper, a new IC has been proposed for detection of bleeding region in the GI tract, to be implemented inside the capsule endoscope. In this design, firstly, by combining the image characteristics of RGB and HSI color image spaces as well as making the algorithm adaptive to image luminance, the most optimal algorithm considering the bleeding detection evaluation parameters, have been proposed; the results have shown a 5% improvement in comparison with the most efficient existing work. In contrast with the previous works, the proposed algorithm has been developed as a hardware implementation using 7-stage pipeline architecture and the input image format of Bayer CFA. The operational frequency of this circuit is 250MHz that can process each Bayer format endoscope image in less than 60μs. The whole architecture has been described by VerilogHDL and synthesized on ALTERA Stratix II FPGA.