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Effects of cyclic stretch on early response gene expressions in normal human pulmonary artery endothelial cells in vitro

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8 Author(s)
Kobayashi, K. ; Grad. Sch. of Med. Sci., Kitasato Univ., Sagamihara, Japan ; Tanaka, M. ; Inaoka, H. ; Nebuya, S.
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The effects of cyclic stretch (within 30 min) on the expressions of early response genes in normal human pulmonary artery endothelial cells (HPAEC) were investigated using an in vitro stretch system. The investigated early response genes were early growth response gene 1 (Egr1), heat-shock protein 4 (Hspa4), PTGS4 (cox2) and the inflammatory cytokines interleukin (IL)-1, IL-6 and IL-8. The genes of Egr1 and PTGS2 were upregulated at early stages by cycle stretch.

Published in:
Bioinformatics and Biomedicine Workshops (BIBMW), 2010 IEEE International Conference on

Date of Conference: 18-18 Dec. 2010

Page(s):
857 - 858
E-ISBN :
978-1-4244-8304-4
Print ISBN:
978-1-4244-8303-7
INSPEC Accession Number:
11793464
Conference Location :
Hong, Kong
Digital Object Identifier :
10.1109/BIBMW.2010.5703944
Product Type:
Conference Publications

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