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A Lab-on-Chip system is proposed, capable of SNP (Single Nucleotide Polymorphism) detection in DNA. One of the core components is an advanced filter consisting of an ordered array of Si micro-pillars enabling fast and effective separation of 5 DNA segments with different length using chromatographic techniques. Also a dedicated micro-pump is fabricated based on conductive polymer actuation, generating the required high pressure to sustain the fluid flow through the total system. For the detector, a known detector principle is applied, but pronounced miniaturization is carried out in order to make a small and portable system.