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Secondary-flow-induced label-free continuous cell sorting using antibody-immobilized micro oblique grooves

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4 Author(s)
Shin-ichi Hashimoto ; Department of Mechanical Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-8656, Japan ; Nai-hsuan Chen ; Yuji Suzuki ; Nobuhide Kasagi

A new label-free continuous cell sorting method has been developed for accurate extraction of rare cell. The sorting mechanism is based on antigen-antibody interaction and the secondary flow induced by oblique micro grooves on the channel surface. Specific adhesion between the cell membrane and the wall surface keep the target cells rolling on the wall, while the lateral flow along the groove induces cross-flow displacement of the target cell. Successful separation of cell models and human umbilical-vein endothelial cells (HUVEC) fully supports the proposed mechanism.

Published in:

Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference on

Date of Conference:

17-20 Aug. 2010