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A novel hybrid algorithm Quantum Immune (QI), which combines Quantum Algorithm (QA) and Immune Clonal Selection (ICS) Algorithm, has been presented for dealing with multi-extremum and multi-parameter problem based on AB off-lattice model in the predicting 2D protein folding structure. Clonal Selection Algorithm was introduced into the hyper mutation operators in the Quantum Algorithm to improve the local search ability, and double chains quantum coded was designed to enlarge the probability of the global optimization solution. It showed that the solution mostly trap into the local optimum, to escape the local best solution the aging operator is introduced to improve the performance of the algorithm. Experimental results showed that the lowest energies and computing-time of the improved Quantum Clonal Selection (QCS) algorithm were better than that of the previous methods, and the QCS was further improved by adding aging operator to combat the premature convergence. Compared with previous approaches, the improved QCS algorithm remarkably enhanced the convergence performance and the search efficiency of the immune optimization algorithm.