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The 13th IEEE International Conference on Computational Science and Engineering (CSE-2010) was held in Hong Kong, China, December 11-13, 2010. Computational Science and Engineering is increasingly emerging as a promising discipline in shaping future research and development activities in academia and industry, ranging from engineering, science, finance, economics, arts and humanitarian fields, especially when the solution of large and complex problems must cope with tight timing schedules. CSE-2010 is the next event, in a series of highly successful International Conferences on Computational Science and Engineering (CSE), held mainly as the International Workshop on High Performance Scientific and Engineering Computing for 10 editions, mostly in conjunction with International Conference on Parallel Processing (ICPP), as COATA-98 (Orlando, USA, July 1998), HPSEC-99 (Fukushima, Japan, September 1999), HPSEC-00 (Toronto, Canada, August 2000), HPSEC-01 (Valencia, Spain, September 2001), HPSEC-02 (Vancouver, Canada, August 2002), HPSEC-03 (Kaohsing, Taiwan, October 2003), HPSEC-04 (Montreal, Canada, August 2004), HPCSE-04 with WCC-04 (Toulouse, France, August 2004), HPSEC-05 (Oslo, Norway, June 2005), and HPSEC-06 (Columbus, USA, August 2006). The previous CSE-08 and CSE-09 were held in S??o Paulo, Brazil, July 16-18, 2008 and Vancouver, Canada, August 29-31, 2009.