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The 13th IEEE International Conference on Computational Science and Engineering (CSE-2010) was held in Hong Kong, China, December 11-13. This 2010 edition of CSE consists of 37 papers selected from 230 submissions, giving an acceptance rate of 16%. We wish to acknowledge the authors for choosing CSE-2010 as the venue to present their research. The final decision has been taken after a high quality review process that produced at least three reviews per paper (four or five reviews in most cases), involving more than 200 program committee members. Fortunately, we were well assisted by 13 Program Vice-Chairs, reputed experts in their fields.